Nano Transistors for Detection of Cardiac Troponin- Dr. Xiong

The polypeptide chains cTnI and cTnT of the cardiac troponin complex in the blood plasma are considered ‘gold standard’ biomarkers for early detection of myocardial ischemia. INSI faculty members Bryant Chase (Biology), Geoffrey Strouse (Chemistry) and Peng Xiong (Physics), with their collaborators Linda Hirst (Physics, UC Merced), Zhong-Lin Wang (MSE, GaTech), and Jim Zheng (ECE, FAMU/FSU), have developed a semiconductor nano sensor for the detection of cTn, as a first step towards a portable sensing platform for rapid, on-site diagnosis of myocardial ischemia. The devices are field-effect transistors based on semiconducting oxide (SnO2) nanobelts which are selectively functionalized with appropriate antibodies. The detection of the antigen is based on electrical conductance change resulting from the antibody-antigen binding on the nanobelt surface.

The research was conducted by an interdisciplinary group of students: Yi Cheng, Kan-Sheng Chen, Tim Keiper, Jorge Barreda, Anthony Hazel (Physics), Nancy Meyer, Myriam Badr (Biology), Lenwood Fields (ECE), Ruseng Yang (MSE). The work was supported by NSF, NIH, and FSU Research Foundation.

From additional information contact: Peng Xiong  email: xiong@martech.fsu.edu

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